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Representative immunostaining of gynecologic PEComas. (A) Case 7 <t>demonstrating</t> <t>HMB45</t> diffuse positivity. (B) Case 7 exhibiting focal immunoresponse for MelanA. (C) Lack of S-100 in tumor cells. (D) Diffuse staining of SMA in tumor cells. (E) Totally negative for <t>desmin.</t> (F) Typically diffuse positivity of TFE3. (G) Absence of Vimentin in this tumor. (H) PR positivity present in a subset of gynecologic PEComas.
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Representative immunostaining of gynecologic PEComas. (A) Case 7 <t>demonstrating</t> <t>HMB45</t> diffuse positivity. (B) Case 7 exhibiting focal immunoresponse for MelanA. (C) Lack of S-100 in tumor cells. (D) Diffuse staining of SMA in tumor cells. (E) Totally negative for <t>desmin.</t> (F) Typically diffuse positivity of TFE3. (G) Absence of Vimentin in this tumor. (H) PR positivity present in a subset of gynecologic PEComas.
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Representative immunostaining of gynecologic PEComas. (A) Case 7 <t>demonstrating</t> <t>HMB45</t> diffuse positivity. (B) Case 7 exhibiting focal immunoresponse for MelanA. (C) Lack of S-100 in tumor cells. (D) Diffuse staining of SMA in tumor cells. (E) Totally negative for <t>desmin.</t> (F) Typically diffuse positivity of TFE3. (G) Absence of Vimentin in this tumor. (H) PR positivity present in a subset of gynecologic PEComas.
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Representative immunostaining of gynecologic PEComas. (A) Case 7 demonstrating HMB45 diffuse positivity. (B) Case 7 exhibiting focal immunoresponse for MelanA. (C) Lack of S-100 in tumor cells. (D) Diffuse staining of SMA in tumor cells. (E) Totally negative for desmin. (F) Typically diffuse positivity of TFE3. (G) Absence of Vimentin in this tumor. (H) PR positivity present in a subset of gynecologic PEComas.

Journal: Frontiers in Oncology

Article Title: Clinicopathological and molecular features of gynecologic perivascular epithelioid cell tumors: a single-center study

doi: 10.3389/fonc.2026.1769702

Figure Lengend Snippet: Representative immunostaining of gynecologic PEComas. (A) Case 7 demonstrating HMB45 diffuse positivity. (B) Case 7 exhibiting focal immunoresponse for MelanA. (C) Lack of S-100 in tumor cells. (D) Diffuse staining of SMA in tumor cells. (E) Totally negative for desmin. (F) Typically diffuse positivity of TFE3. (G) Absence of Vimentin in this tumor. (H) PR positivity present in a subset of gynecologic PEComas.

Article Snippet: Then primary monoclonal antibody (ready-to-use) against HMB45(clone HMB45), MelanA (OTI12H10), SMA (UMAB237), Caldesmon (EP19), desmin (OTIR4A8), TFE3(EP285), S-100(15E2E2 + 4C4.9), CKpan(AE1/AE3), EMA (GP1.4), Vimentin (UMAB159) and ki-67 (UMAB107) from Zhongshan Bio-Tech(Beijing), ER (SP1, Roche) and PR(1E2, Roche) were applied to the sections.

Techniques: Immunostaining, Staining